FARE recommends allowing your epinephrine auto-injectors to pass through the x-ray machines and security scanners used to screen carry-on luggage in airport security.
While there is limited research on this topic, after searching the published medical literature, FARE does not believe any scientific evidence exists that indicates a risk to the effectiveness of the medication, due to the fact that the amount of radiation emitted by an airport x-ray machine is similar to the amount of ambient radiation everyone experiences in a typical day on planet Earth.
In addition, the x-ray machine is recommended over visual inspections of a device by TSA officials because visual inspections may increase the risk of accidental activation of or damage to the device, and the risk of losing the device.
Always keep your epinephrine with you; do not store in the overhead bin or in a checked bag. Let others you are traveling with know about your allergies so they know what to do in case of an emergency on the flight and where your auto-injector is located.
More information about traveling with medications and the effects of airport x-ray systems on medication are available from the U.S. Food and Drug Administration and Transportation Security Administration (TSA).